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Having dispensed with former colleagues O-Ren Ishii (Lucy Liu) and Vernita Green (Vivica A. Fox), the Bride (Uma Thurman) resumes her quest for justice. With those two down, she has two remaining foes on her "Death List" to pursue — Budd (Michael Madsen) and Elle Driver (Daryl Hannah) — before moving on to her ultimate goal... to kill Bill (David Carradine).